Apply the cream to skin around lymph node regions closest to the region of concern (the green regions in the diagram). If your issue is non-topical, or you are using for general immune boosting or preventative purposes, you may apply the cream to the lower left or right part of your neck. The cream is transdermal and designed to absorb through the skin into the lymphatic system.
For specific skin issues you may also apply the cream directly to the affected areas, so long as there is open no wounds or lesions. This can be done by alternating applying it topically in the morning and then to the nearest lymph node region in the evening. For cosmetic purposes you may also rub the cream across the face and decolletage.